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  • Title: [The clinical and laboratory diagnosis of sCJD and vCJD].
    Author: Kulczycki J, Łojkowska W.
    Journal: Neurol Neurochir Pol; 2003; 37 Suppl 2():7-14. PubMed ID: 14560703.
    Abstract:
    Clinical diagnosis of sporadic CJD is usually confirmed by a typical EEG pattern and an increased level of protein 14-3-3 in the CSF, with specificity of 74% and 84%, respectively. However, both these tests are often negative in vCJD patients. Recently MR imaging has substantially improved the diagnosis of sCJD and vCJD. In sCJD patients hyperintense signal in T2-weighted sequences was found to be present in the neostriatum (the caudate nucleus and putamen) with specificity of 93%, while in vCJD cases signal hyperintensity was found in pulvinar thalami. The "pulvinar sign" was evidenced to be highly sensitive (79%) and specific (100%) for the diagnosis of the latter form of CJD.
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