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  • Title: A pilot study of screening for neuroblastoma in the north of England.
    Author: Craft AW, Parker L, Dale G, McGill AC, Seviour JA, Bell S, Cole M, Smith J.
    Journal: Am J Pediatr Hematol Oncol; 1992 Nov; 14(4):337-41. PubMed ID: 1456400.
    Abstract:
    A pilot study has been carried out to assess the feasibility of screening for neuroblastoma in 6-month-old infants in the north of England. A total of 20,829 infants were screened. Two true-positive cases were found, along with eight false-positive and three false-negative cases. It was shown that the concentrations of catecholamine metabolites in the urine are dependent on the creatinine content; centiles have been established to allow this relationship to be taken into account. Five of the eight false-positive cases would have been correctly assessed as normal if the new centiles had been used. Preliminary results lend support to the need for a well-designed study of neuroblastoma screening to be carried out, with death from this disease as the only end point.
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