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  • Title: Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-adenosylhomocysteine hydrolase.
    Author: Jeong LS, Moon HR, Park JG, Shin DH, Choi WJ, Lee KM, Kim HO, Chun MW, Kim HD, Kim JH.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2003; 22(5-8):589-92. PubMed ID: 14565234.
    Abstract:
    Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.
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