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  • Title: Novel nucleotide analogues as potential substrates for TMPK, a key enzyme in the metabolism of AZT.
    Author: Müller HC, Meier C, Balzarini J, Reinstein J.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2003; 22(5-8):821-3. PubMed ID: 14565287.
    Abstract:
    Novel cyclic and acyclic analogues of dTMP and AZTMP were synthesized from the corresponding cycloSal-phosphotriesters. This method yielded the nucleotides in good yields with a simple work-up. Investigation of the substrate properties of the modified nucleotides towards TmpK showed, that they are very poor substrates for this key enzyme in the bioactivation of AZT.
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