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  • Title: Non-inhibition of acetylcholinesterase by cycloSal nucleotides.
    Author: Ducho C, Balzarini J, Meier C.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2003; 22(5-8):841-3. PubMed ID: 14565292.
    Abstract:
    An acetylcholinesterase (AChE) assay based on the Rappaport method was established to investigate the behaviour of several cycloSal nucleotides against AChE from electrophorus electricus and human sources (purified enzymes). AChE is a physiologically essential enzyme as it catalyzes the hydrolysis of the neurotransmitter acetylcholine. No inhibition was observed in any of the cases.
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