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  • Title: Mononucleoside SATE glucosyl phosphorothiolates as a new series of pronucleotides.
    Author: Jochum A, Schlienger N, Gosselin G, Imbach JL, Aubertin AM, Périgaud C.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2003; 22(5-8):899-901. PubMed ID: 14565306.
    Abstract:
    The synthesis and the study of two phosphorothiolate derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a S-pivaloyl-2-thioethyl (tBuSATE) group and glucosyl residues associated to the phosphorus atom by a 2-oxyethyl link, are reported. These derivatives could be considered as prototypes of a new series of nucleotide prodrugs (pronucleotides).
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