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  • Title: Synthesis and studies of modified oligonucleotides-directed triple helix formation at the purine-pyrimidine interrupted site.
    Author: Jazouli M, Guianvarc'h D, Bougrin K, Soufiaoui M, Vierling P, Benhida R.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2003; 22(5-8):1277-80. PubMed ID: 14565398.
    Abstract:
    Triple helix formation is still restricted to oligopurine-oligopyrimidine double stranded DNA target. Herein we focus on our progress achieved in nucleobase and oligonucleotide modifications area to address the chemical challenge to circumvent the recognition of a purine-pyrimidine base pair interruption in an oligopyrimidine-oligopurine DNA sequence.
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