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  • Title: Structure of 2',5'-linked tetraribonucleotide loops: a novel RNA motif.
    Author: Hannoush RN, Denisov AY, Gehring K, Damha MJ.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2003; 22(5-8):1687-90. PubMed ID: 14565496.
    Abstract:
    We report on the three dimensional structure of an RNA hairpin containing a 2',5'-linked tetraribonucleotide loop, namely, 5'-rGGAC(UUCG)GUCC-3' (where UUCG = U(2'p5')U(2'p5')C(2'p5')G(2'p5')). We show that the 2',5'-linked RNA loop adopts a conformation that is quite different from that previously observed for the native 3',5'-linked RNA loop. The 2',5'-RNA loop is stabilized by (a) U:G wobble base pairing, with both bases in the anti conformation, (b) extensive base stacking, and (c) sugar-base contacts, all of which contribute to the extra stability of this hairpin structure.
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