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  • Title: Performance prediction of industrial centrifuges using scale-down models.
    Author: Boychyn M, Yim SS, Bulmer M, More J, Bracewell DG, Hoare M.
    Journal: Bioprocess Biosyst Eng; 2004 Dec; 26(6):385-91. PubMed ID: 14566553.
    Abstract:
    Computational fluid dynamics was used to model the high flow forces found in the feed zone of a multichamber-bowl centrifuge and reproduce these in a small, high-speed rotating disc device. Linking the device to scale-down centrifugation, permitted good estimation of the performance of various continuous-flow centrifuges (disc stack, multichamber bowl, CARR Powerfuge) for shear-sensitive protein precipitates. Critically, the ultra scale-down centrifugation process proved to be a much more accurate predictor of production multichamber-bowl performance than was the pilot centrifuge.
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