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  • Title: Complex segregation analysis of 1,792 cleft lip and palate families in South America: 1967-1997.
    Author: Vieira AR, Romitti PA, Orioli IM, Castilla EE.
    Journal: Pesqui Odontol Bras; 2003; 17(2):161-5. PubMed ID: 14569360.
    Abstract:
    Although several studies have demonstrated familial aggregation of nonsyndromic cleft lip with or without cleft palate (CL/P), its model of inheritance remains uncertain. We report the results of complex segregation analysis performed in South American families with a newborn affected with CL/P. Families of 1,792 consecutive newborns affected with CL/P and registered during the period 1967 to 1997 were studied. A model that did not include a major locus was the best-fitting model for CL/P families. This result is in agreement with previous studies which showed a significant association of several putative susceptibility loci and CL/P, indicating that the genes involved in CL/P are likely to have only a very modest impact on disease risk.
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