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  • Title: Glycogen metabolism during human liver development.
    Author: Devi BG, Habeebullah CM, Gupta PD.
    Journal: Biochem Int; 1992 Oct; 28(2):229-37. PubMed ID: 1456947.
    Abstract:
    Development of enzymes of glycogen metabolism in human fetal and neonatal liver was investigated. Glycogen was present in quantitatable amount from early gestational age onwards; however, ultrastructurally it could not be detected earlier than 20 weeks. Increase in glycogen synthetase a activity during 21-36 weeks of gestation subsequently resulted in glycogen accumulation. A rapid degradation of this glycogen storage, at birth, was accompanied by an elevation in glycogen phosphorylase a activity. The present investigation to be the first to provide a complete profile of glycogen storage and differentiation of glycogen metabolising enzymes in preparing the prenatal fetus for its independent nutritional life.
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