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  • Title: Ventilatory management of respiratory failure in patients with severe Guillain-Barre syndrome.
    Author: Aggarwal AN, Gupta D, Lal V, Behera D, Jindal SK, Prabhakar S.
    Journal: Neurol India; 2003 Jun; 51(2):203-5. PubMed ID: 14571003.
    Abstract:
    Guillain-Barre syndrome (GBS) is the commonest peripheral neuropathy causing ventilatory failure, and 10-30% patients may require respiratory support. Records of 11 adult patients of GBS in respiratory failure, admitted to the Respiratory Intensive Care Unit (RICU) of our institute for mechanical ventilation over a four-year period, were studied. Six patients received intravenous immunoglobulin. The median duration of mechanical ventilation was 38 days. Seven patients underwent tracheostomy. Four patients were ventilated for less than 2 weeks and 3 for more than 2 months each. Seven developed ventilator-associated pneumonia and/or sepsis. Three patients died in, and two shortly after discharge from RICU; all had systemic problems or complications of hospitalization.
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