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  • Title: O-nucleophilic amino alcohol acyl-transfer catalysts: the effect of acidity of the hydroxyl group on the activity of the catalyst.
    Author: Wayman KA, Sammakia T.
    Journal: Org Lett; 2003 Oct 30; 5(22):4105-8. PubMed ID: 14572260.
    Abstract:
    [reaction: see text]. Amino alcohol-derived acyl-transfer catalysts are shown to operate by an O-nucleophilic mechanism, and catalysts bearing electron-withdrawing groups in proximity to the hydroxyl group are found to be more active. This is attributed to an increase in the acidity of the hydroxyl group of the catalyst.
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