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  • Title: Cytotoxic constituents of Isodon rubescens var. lushiensis.
    Author: Han QB, Zhao AH, Zhang JX, Lu Y, Zhang LL, Zheng QT, Sun HD.
    Journal: J Nat Prod; 2003 Oct; 66(10):1391-4. PubMed ID: 14575445.
    Abstract:
    Five new ent-kaurane diterpenoids, ludongnins F-J (1-5), along with 10 known compounds, guidongnins A-C (6-8), angustifolin (9), 6-epiangustifolin (10), sculponeatin J (11), gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis. The structures of 1-5 were determined by spectroscopic analysis, as well as X-ray crystallographic analysis of 1. Compounds 1-11 were evaluated against K562 leukemia cells for their cytotoxic effects.
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