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  • Title: [Structural changes of chromatin during proto-oncogene activation by cycloheximide: dose-effect].
    Author: Shevchenko NA, Spitkovskiĭ DD, Loginov AS, Makar'eva ED, Boĭkov PIa.
    Journal: Biokhimiia; 1992 Oct; 57(10):1491-8. PubMed ID: 1457595.
    Abstract:
    The level of expression of cellular proto-oncogens c-myc and c-fos in rat liver has been studied as a function of protein synthesis rate (cycloheximide dose). Activation of proto-oncogens has been established to be initiated by 50% inhibition of nuclear protein synthesis. This promotes a certain level in chromatin structural rearrangements which is manifested, in particular, in decreasing activity of chromatin cleavage by Ca2+, Mg(2+)-DNAase and increasing degree of chromatin condensation. A role of topoisomerase II in chromatin structural rearrangements during proto-oncogen activation is postulated.
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