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  • Title: Activity of posaconazole in treatment of experimental disseminated zygomycosis.
    Author: Dannaoui E, Meis JF, Loebenberg D, Verweij PE.
    Journal: Antimicrob Agents Chemother; 2003 Nov; 47(11):3647-50. PubMed ID: 14576138.
    Abstract:
    Three isolates of zygomycetes were used to produce a disseminated infection in nonimmunocompromised mice. Against all zygomycete strains, amphotericin B significantly prolonged survival. Itraconazole was inactive against Rhizopus microsporus and Rhizopus oryzae but was partially active against Absidia corymbifera. Posaconazole had no beneficial effects against R. oryzae but showed partial activity against A. corymbifera. Posaconazole had a clear dose-response effect against R. microsporus.
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