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  • Title: Multicentric Castleman's disease associated with inherited epidermolysis bullosa.
    Author: Kawakami Y, Nishibu A, Kikuchi S, Ohtsuka M, Nakamura K, Nozawa Y, Abe M, Iwatsuki K, Kaneko F.
    Journal: J Dermatol; 2003 Sep; 30(9):689-93. PubMed ID: 14578560.
    Abstract:
    Multicentric Castleman's disease (MCD) is a rare disorder characterized by fever, polyclonal hypergammaglobulinemia, and generalized lymphadenopathy. It has three histological characteristics: a recognizable architecture, germinal center abnormalities, and plasmacytosis. Inherited epidermolysis bullosa (EB) is also a rare disorder caused by a genetic defect. We report a 43-year-old patient with dystrophic EB, non-Hallopeau-Siemens recessive type or dominant type, displaying clinicopathologic features of MCD. In addition, his serum interleukin-6, which is thought to be responsible for the clinical symptoms in MCD, was elevated.
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