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  • Title: [The effect of clofelin on uterine contractile activity (experimental and clinical research)].
    Author: Khushvakhtova EKh, Arzhanova NO, Zaĭtseva AA.
    Journal: Eksp Klin Farmakol; 1992; 55(4):23-4. PubMed ID: 1458180.
    Abstract:
    Pregnant rat experiments have revealed a pronounced and prolonged naloxone-irreversible depriming effect of clofelin, 0.05 and 0.5 mg/kg, on the frequency and amplitude of myometrial biopotentials, which was eliminated with phenoxybenzamine. In clinical testing, clofelin in therapeutical doses showed a marked tocolytic effect in threatened abortion at 18-34-week gestation. The agent in the same doses normalized blood pressure in hypertensive pregnants, without having a negative action on the fetus.
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