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  • Title: [The antithromboxane activity of alpha- and omega-modified carbocyclic analogs of PGH1].
    Author: Kuz'mitskiĭ BB, Bondar' NF, Malaeva LP.
    Journal: Eksp Klin Farmakol; 1992; 55(4):31-3. PubMed ID: 1458183.
    Abstract:
    In in vitro experiments on a model of arachidonate- and thrombin-induced platelet aggregation, analogues of PG endoperoxides displayed an antiaggregatory effect or stimulated spontaneous platelet aggregation in the whole blood of man and rabbits, but a slight antiaggregatory effect in the rabbit intact organism. The presence of the hydroxyl group instead of the routine alkyl omega-chain produced an antiaggregatory effect due to TxA2 receptor blockade.
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