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  • Title: Mechanobiology of cartilage: how do internal and external stresses affect mechanochemical transduction and elastic energy storage?
    Author: Silver FH, Bradica G.
    Journal: Biomech Model Mechanobiol; 2002 Dec; 1(3):219-38. PubMed ID: 14586701.
    Abstract:
    Articular cartilage is a multilayered structure that lines the surfaces of all articulating joints. It contains cells, collagen fibrils, and proteoglycans with compositions that vary from the surface layer to the layer in contact with bone. It is composed of several zones that vary in structure, composition, and mechanical properties. In this paper we analyze the structure of the extracellular matrix found in articular cartilage in an effort to relate it to the ability of cartilage to store, transmit, and dissipate mechanical energy during locomotion. Energy storage and dissipation is related to possible mechanisms of mechanochemical transduction and to changes in cartilage structure and function that occur in osteoarthritis. In addition, we analyze how passive and active internal stresses affect mechanochemical transduction in cartilage, and how this may affect cartilage behavior in health and disease.
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