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  • Title: Long-term follow-up of type II membranoproliferative glomerulonephritis in two children.
    Author: Iitaka K, Nakamura S, Moriya S, Koshino H, Iwasaki N, Motoyama O, Sakai T.
    Journal: Clin Exp Nephrol; 2003 Mar; 7(1):58-62. PubMed ID: 14586745.
    Abstract:
    We report the long-term follow-up of two patients with type II membranoproliferative glomerulonephritis (MPGN). One Patients was treated with high-dose alternate-day prednisolone and the other with dipyridamole. Both had favorable clinical courses over 8.5 and 15.5 years of follow-up, respectively. One patient who showed diffuse proliferative changes lost the urinary abnormalities 2 years after starting treatment. Her follow-up renal biopsies showed histological improvement. In the other patient, a boy, renal biopsy performed 6 years after the onset showed mild mesangial proliferation and a moderate matrix increase. His urine became normal 14 years after onset. Intramembranous electron-dense deposits persisted in these patients over 7 and 6 years of observation, respectively. Patients with type II MPGN are usually difficult to treat and often progress to endstage renal failure. There is, however, a group of patients who have a favorable clinical course.
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