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  • Title: Glomerular immune deposits in murine lupus models may contain histones.
    Author: Schmiedeke T, Stoeckl F, Muller S, Sugisaki Y, Batsford S, Woitas R, Vogt A.
    Journal: Clin Exp Immunol; 1992 Dec; 90(3):453-8. PubMed ID: 1458682.
    Abstract:
    Two types of lupus mice, NZB/NZW F1 female hybrids and mice with graft-versus-host disease (GVHD), were studied. Histones H3 and H2A were detected by immunofluorescence in glomeruli of 22/22 proteinuric GVHD and 8/12 proteinuric NZB/W F1 female mice; in non-proteinuric animals, 3/5 GVHD and 2/27 NZB/W F1 female were positive. Using antibodies to histone peptides it was shown that mainly the N-terminal regions of histones H3 and H2A were exposed in glomerular deposits. Western blot analysis revealed antibodies to histone subfractions in sera of 33/34 lupus mice that developed proteinuria. This study provides evidence that histones are involved in the pathogenesis of lupus nephritis.
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