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  • Title: Rapid screening by MALDI-TOF mass spectrometry to probe binding specificity at enzyme active sites.
    Author: Webb ME, Stephens E, Smith AG, Abell C.
    Journal: Chem Commun (Camb); 2003 Oct 07; (19):2416-7. PubMed ID: 14587709.
    Abstract:
    The binding affinity of aspartate decarboxylase has been probed using MALDI-TOF spectrometry; adducts formed covalently in the active site were detected by MALDI-TOF mass spectrometry after incubation of the enzyme with a range of potential ligands in the presence of NaCNBH3; this has highighted key structural features which will aid design of potential inhibitors.
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