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  • Title: A new class of glycogen phosphorylase inhibitors.
    Author: Lu Z, Bohn J, Bergeron R, Deng Q, Ellsworth KP, Geissler WM, Harris G, McCann PE, McKeever B, Myers RW, Saperstein R, Willoughby CA, Yao J, Chapman K.
    Journal: Bioorg Med Chem Lett; 2003 Nov 17; 13(22):4125-8. PubMed ID: 14592521.
    Abstract:
    A new class of diacid analogues that binds at the AMP site not only are very potent but have approximately 10-fold selectivity in liver versus muscle glycogen phosphorylase (GP) in the in vitro assay. The synthesis, structure, and in vitro and in vivo biological evaluation of these liver selective glycogen phosphorylase inhibitors are discussed.
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