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  • Title: [The laminopathy saga].
    Author: Bonne G.
    Journal: Rev Neurol; ; 37(8):772-4. PubMed ID: 14593639.
    Abstract:
    AIMS: Our aim was to clinically characterise Emery-Dreifuss muscular dystrophy, to differentiate the X-linked forms of inheritance from the forms involving autosomal dominant inheritance, from a genetic point of view, and to describe the phenotypical heterogeneity of mutations in the LMNA gene itself. DEVELOPMENT: We describe the identification of the mutations in the lamina A/C gene, the LMNA gene, which was made possible thanks to the networks allowing workers in different countries to collaborate. Mutations in this gene are responsible for autosomal dominant Emery-Dreifuss disease, as well as other diseases that are phenotypically very distinct, such as limb girdle muscular dystrophy associated with cardiac conduction defects (LGMD1B), dilated myocardiopathy with conduction defects (DCM-CD), Dunnigan-type familial partial lipodystrophy (FPLD) and, finally, an autosomal recessive form of axonal neuropathy or Charcot-Marie-Tooth disease type 2 (AR-CMT). CONCLUSIONS: Laminas are intermediate filaments that constitute the inner nuclear membrane of any cell and the mutations in the lamina A/C gene can give rise to such distinct clinical patterns as a kind of muscular dystrophy that is similar to the well known X-linked Emery-Dreifuss disease or a form of Charcot-Marie-Tooth-type neuropathy. Work is currently being conducted on an experimental animal model capable of providing us with a better understanding of the physiopathological mechanisms involved in the production of these tissue-specific diseases, although they are due to mutations in a gene that codifies for proteins that are expressed all over.
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