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  • Title: [Current therapies for parkinson's disease. Part II: surgical treatment].
    Author: Słowiński J, Wharen RE, Uitti RJ, Wszolek ZK, Krygowska-Wajs A, Mrówka R.
    Journal: Neurol Neurochir Pol; 2003; 37(3):677-86. PubMed ID: 14593761.
    Abstract:
    Surgical treatment of Parkinson's disease (PD) is indicated in patients with severe neurological symptoms (tremor, bradykinesia, rigidity)--who do not benefit from nor tolerate pharmacological therapy. Surgery for PD modifies the motor system function by lesioning or electrostimulation of thalamic, pallidal or subthalamic nuclei. The technological progress together with refined CNS monitoring enabled wider application of deep brain stimulation (DBS). The efficacy of DBS is comparable with lesioning techniques (thalamotomy or pallidotomy) however bears less adverse effects. Both lesioning and DBS are generally well tolerated by patients. The side effects are mostly transient and neurological complications, if occur, usually do not affect quality of patient's life. Unfortunately, the modern surgery for PD is still very expensive and demanding for a large team of specialists and high technology.
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