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  • Title: Initiation on chromatin templates in a yeast RNA polymerase II transcription system.
    Author: Lorch Y, LaPointe JW, Kornberg RD.
    Journal: Genes Dev; 1992 Dec; 6(12A):2282-7. PubMed ID: 1459452.
    Abstract:
    Templates were prepared with either the TATA box or transcription start sites of the yeast CYC1 promoter in a nucleosome. In both cases, initiation in an unfractionated yeast RNA polymerase II transcription system was abolished by the nucleosome. The inhibition appeared to be relieved by the activator protein Gal4-VP16 binding to a site upstream of the promoter. Inhibition was not relieved, however, in a transcription system reconstituted from purified components, indicating a requirement for additional factors for the effect of Gal4-VP16.
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