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  • Title: Impact of graft diameter on corneal power and the regularity of postkeratoplasty astigmatism before and after suture removal.
    Author: Seitz B, Langenbucher A, Küchle M, Naumann GO.
    Journal: Ophthalmology; 2003 Nov; 110(11):2162-7. PubMed ID: 14597524.
    Abstract:
    OBJECTIVE: To assess the impact of graft diameter on corneal curvature before and after removal of a double-running suture after nonmechanical penetrating keratoplasty (PK). DESIGN: Prospective, nonrandomized, comparative (self-controlled) single-center clinical trial. PATIENTS: Four hundred eighty-nine eyes with "two sutures in" and 308 eyes with "all sutures out" (mean age, 52+/-19 years) were included. The diagnoses were keratoconus (48%), Fuchs' and stromal dystrophies (31%), aphakic or pseudophakic bullous keratopathy (11%), and scars (10%). INTERVENTIONS: In all eyes, a central trephination was performed (donor trephination from the epithelial side) using the 193-nm Meditec excimer laser (Carl Zeiss Meditec, Jena, Germany) along metal masks with eight "orientation teeth/notches." Diameters were 8.0 mm, 7.5 mm, and 7.0 mm with a graft oversize of 0.1 mm. In 29% of eyes, additional cataract, intraocular lens surgery, or both were performed simultaneously. In all eyes, a double-running 10-0 nylon suture was applied. Zeiss keratometry and TMS-1 topography analysis were performed before removal of the first suture (14+/-4 months) and at least 6 weeks after removal of the second suture (20+/-4 months), but before any additional surgery, such as cataract extraction or refractive keratotomies. MAIN OUTCOME MEASURES: Topographic central corneal power (CP; keratometric diopters), keratometric astigmatism (KA), surface regularity index (SRI), and surface asymmetry index (SAI). The regularity of keratometry mires was recorded semiquantitatively from 0 = regular to 3 = not measurable (as published earlier). RESULTS: With both sutures in, median CP in 7.0-mm (42.0 diopters [D]; P = 0.04) and in 7.5-mm grafts (42.3 D; P = 0.007) was significantly lower than in 8.0-mm grafts (43.0 D). Keratometric astigmatism did not differ between groups (3.0 D vs. 3.0 D vs. 2.7 D). The SRI (1.66 vs. 1.43 vs. 1.11) and SAI (1.55 vs. 1.24 vs. 0.85) decreased significantly with increasing diameter. The proportion of regular keratometry mires (13% vs. 17% vs. 29%) increased, and the proportion of not measurable keratometries (45% vs. 18% vs. 9%) decreased with increasing diameter. With all sutures out, CP in 7.0-mm grafts (40.4 D) was significantly smaller than in 7.5-mm (43.6 D; P = 0.04) and 8.0-mm grafts (43.3 D; P = 0.04). Again, KA did not differ between groups (3.0 D vs. 3.2 D vs. 3.0 D). The SRI (1.40 vs. 1.09 vs. 0.84) and SAI (1.24 vs. 0.83 vs. 0.62) decreased significantly with increasing diameter. The proportion of regular keratometry mires (5% vs. 31% vs. 52%) increased, and the proportion of not measurable keratometries (42% vs. 11% vs. 4%) decreased with increasing diameter. CONCLUSIONS: After PK, a smaller graft diameter results in a flatter curvature and a higher degree of topographic irregularity, but not in higher net astigmatism. After suture removal, graft topography tends to regularize, whereas the principal differences between diameters do persist.
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