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  • Title: Levodopa pharmacokinetics and dyskinesias: are there sex-related differences?
    Author: Martinelli P, Contin M, Scaglione C, Riva R, Albani F, Baruzzi A.
    Journal: Neurol Sci; 2003 Oct; 24(3):192-3. PubMed ID: 14598082.
    Abstract:
    We examined the potential sex-related differences in levodopa pharmacokinetics and their relation with the presence of dyskinesias in a group of 115 patients (67 men, 49 women) with Parkinson's disease. The patients were given a standard oral dose of levodopa plus benserazide (100/25 mg). The area under the levodopa plasma concentration time curve, corrected for the levodopa test dose (in mg/kg body weight), (AUC(w)) was significantly higher in women than in men, with a reduced oral clearance. No difference in the proportion of men and women experiencing dyskinesias was observed.
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