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  • Title: A rat model for acute hepatic failure.
    Author: He Y, Zhou J, Dou KF, Chen Y.
    Journal: Hepatobiliary Pancreat Dis Int; 2003 Aug; 2(3):423-5. PubMed ID: 14599952.
    Abstract:
    OBJECTIVE: To develop a surgical model of acute hepatic failure. METHODS: Hepatectomy was performed in rats according to the method described by Higgins and Anderson. Ninety percent liver resection (removing the left lateral, median, and right lateral lobes) (n=7) and 95% liver resection leaving only half of the caudate lobe (n=13) were performed. Hypoglycemia was corrected by giving 20% glucose in the drinking water, coupled with repeated intraperitoneal injection of 5% glucose adapted to glycemia. While the survival rate, alanine transaminase (ALT) and bilirubin were observed. RESULTS: 95% liver resection decreased survival rates of the rats from 86% (90% liver resection) to 23% (P<0.05), and increased bilirubin levels (4.04+/-2.84 mg/dL vs. 1.25+/-1.85 mg/dL [90% liver resection]). CONCLUSION: 95% liver resection is a good rat model for acute hepatic failure.
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