These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Association of tau gene polymorphism with Parkinson's disease.
    Author: Zappia M, Annesi G, Nicoletti G, Serra P, Arabia G, Pugliese P, Messina D, Caracciolo M, Romeo N, Annesi F, Pasqua AA, Spadafora P, Civitelli D, Romeo N, Epifanio A, Morgante L, Quattrone A.
    Journal: Neurol Sci; 2003 Oct; 24(3):223-4. PubMed ID: 14600827.
    Abstract:
    We investigated the segregation of the dinucleotide GT repeat polymorphism in the intron between exons 9 and 10 of the tau gene in 300 patients with Parkinson's disease (PD) and in 197 normal controls. The A3 allele was more frequent in cases than in controls (30% versus 16%, p<0.001), and individuals carrying at least one A3 allele in their genotype had an increased risk of developing PD (odds ratio 2.78, 95% confidence interval 1.81-4.29). No significant differences were found between patients by considering the age at onset and the presence of family history or dementia. Our findings suggest a possible involvement of the tau gene in the pathogenesis of PD.
    [Abstract] [Full Text] [Related] [New Search]