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  • Title: Genes, culture, and aging flies--what the lab can and cannot tell us about natural genetic variation for senescence.
    Author: Spencer CC, Promislow DE.
    Journal: Sci Aging Knowledge Environ; 2002 May 22; 2002(20):pe6. PubMed ID: 14602988.
    Abstract:
    Model organisms cultured in the lab provide a powerful way to explore basic biological processes. However, lab culture can select for high early fecundity and dramatically shorten the life-span of lab organisms. Studies that use these short-lived organisms to identify aging-related genes might identify genes that simply restore the organism's original life-span. These results might not be fully relevant to wild populations. Experiments that reduce selection for shorter life-span or seek genes in naturally long-lived cohorts should lead to a more accurate understanding of aging.
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