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  • Title: Comparative study of eight well-known polyphenolic antioxidants.
    Author: Cos P, Hermans N, Calomme M, Maes L, De Bruyne T, Pieters L, Vlietinck AJ, Vanden Berghe D.
    Journal: J Pharm Pharmacol; 2003 Sep; 55(9):1291-7. PubMed ID: 14604473.
    Abstract:
    Eight antioxidants from five different polyphenolic classes (cinnamic acids, benzoic acids, flavonoids, proanthocyanidins and stilbenes), and the water-soluble vitamin E derivative trolox were examined for their antioxidant activity in-vitro. In addition, the compounds were tested for their cytotoxicity on growing fibroblasts and their inhibition of the classical pathway of the complement system. Procyanidin C1 was shown to be a good scavenger of both DPPH(*) and HO(*), and a strong inhibitor of lipid peroxidation and the classical pathway of the complement system. Consequently, procyanidin C1 was classified as the most promising antioxidant in-vitro of all compounds tested. In contrast, genistein exhibited a very low antioxidant activity in both the lipid peroxidation and the DPPH(*) scavenging assay, a high cytotoxicity and a low complement-inhibiting activity.
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