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  • Title: Comparison of Etest with modified broth microdilution method for testing susceptibility of Aspergillus spp. to voriconazole.
    Author: Serrano MC, Morilla D, Valverde A, Chávez M, Espinel-Ingroff A, Claro R, Ramírez M, Mazuelos EM.
    Journal: J Clin Microbiol; 2003 Nov; 41(11):5270-2. PubMed ID: 14605181.
    Abstract:
    We compared the Etest with a broth microdilution method, performed according to a modified National Committee for Clinical Laboratory Standards guideline (M38-A), for determining the in vitro susceptibility of 77 isolates of Aspergillus spp. (26 A. fumigatus, 21 A. flavus, 10 A. terreus, 9 A. niger, 5 A. nidulellus, 4 A. glaucus, and 2 A. flavipes isolates). Overall, there was 92.2% agreement between both methods when Etest MICs were read at 24 h and 83.1% agreement when both methods were read at 48 h. When Etest MICs were read at 24 h, the agreement was >90% for all species tested except for A. fumigatus (84.6%). When Etest MICs were read at 48 h, the agreement ranged from 50 to 100%. The poorest agreement was seen with A. glaucus (50%) and A. fumigatus (65%). Where a discrepancy was observed between Etest and the reference method, the Etest MIC was generally higher. The Etest appears to be a suitable alternative procedure for testing the susceptibility of Aspergillus spp. to voriconazole.
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