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  • Title: Interleukin-6 levels in hyperemesis gravidarum.
    Author: Kuscu NK, Yildirim Y, Koyuncu F, Var A, Uyanik BS.
    Journal: Arch Gynecol Obstet; 2003 Nov; 269(1):13-5. PubMed ID: 14605817.
    Abstract:
    INTRODUCTION: Hyperemesis gravidarum (HG) is associated with higher levels of serum beta-hCG levels and hyperthyroidism. Interleukin-6 (IL-6), a pro-inflammatory cytokine, is reported to enhance secretion of beta-hCG from trophoblastic cell line. METHODS: We measured serum levels of IL-6, thyroid hormones and beta-hCG of hyperemetic patients and gestational age-matched controls to search for a difference between the two groups. RESULTS: There was a significant difference in beta-hCG ( p=0.028), though IL-6 levels were higher in the hyperemetic group, it did not reach a significant level. Interleukin-6 positively correlated with beta-hCG ( r=0.38 and p=0.13).
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