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  • Title: Plasma endothelin and nitric oxide levels in patients with acute pancreatitis.
    Author: Zeng XH, Zhu SQ, Zhang XM, Luo WJ, Li SW.
    Journal: Hepatobiliary Pancreat Dis Int; 2002 Feb; 1(1):140-2. PubMed ID: 14607644.
    Abstract:
    OBJECTIVE: To explore the changes of plasma endothelin (ET) and nitric oxide (NO) levels in patients with acute pancreatitis. METHODS: The level of plasma ET was measured by radioactive-immunoassay, and NO by spectrophotometry. RESULTS: The levels of ET, NO and the ET/NO ratio in patients with severe acute pancreatitis (SAP) within 24 hours in hospital were all significantly higher than those in other groups of patients [(176+/-8) pg/ml, (97+/-11) micromol/L, and 1.83+/-0.12, P<0.01]. Compared to healthy controls (N), the levels of ET and NO in patients without pancreatitis acute abdomen (NAP) and patients with mild acute pancreatitis (MAP) increased significantly (P<0.01). After appropriate treatment, the levels of ET and NO in the MAP group were lower (P<0.01). Compared with those before treatment, the levels of ET and NO in the SAP group on the 3rd and 7th day in hospital dropped significantly (P<0.01). The ET/NO ratio on the 7th day was also lower than that on admission (P<0.01). CONCLUSIONS: The malfunction of endothelial cells and the increased ET/NO ratio may be related to the mechanism of pancreatic microcirculatory disturbance in patients with SAP; early dynamic determination of these parameters may help predict the prognosis of SAP.
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