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  • Title: Interaction of beta-blockers and angiotensin receptor blockers/ACE inhibitors in heart failure.
    Author: Cohn JN.
    Journal: J Renin Angiotensin Aldosterone Syst; 2003 Sep; 4(3):137-9. PubMed ID: 14608516.
    Abstract:
    The renin-angiotensin-aldosterone system contributes to the progression of heart failure and its inhibition slows ventricular remodelling and favourably affects morbidity and mortality. beta-blockers exert a remarkably favourable effect on progression that may be mediated at least in part by renin inhibition. Although earlier trials suggested a possible adverse interaction when an angiotensin receptor blocker was added to an angiotensin-converting enzyme inhibitor and a beta-blocker, a recent study and newly analysed mechanistic data indicate that the triple combination provides modest additional inhibition of angiotensin that can further slow progression of disease.
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