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  • Title: Morning pseudoneutropenia during clozapine treatment.
    Author: Esposito D, Aouillé J, Rouillon F, Limosin F.
    Journal: World J Biol Psychiatry; 2003 Oct; 4(4):192-4. PubMed ID: 14608591.
    Abstract:
    Clozapine, an atypical antipsychotic drug, is associated with a high risk of neutropenia and agranulocytosis, necessitating the immediate discontinuation of the drug. We report the case of a patient who developed clozapine-induced neutropenia. Assessments revealed a pronounced diurnal variation in the number of circulating neutrophils (1200-1900/mm(3) in the morning and 2200-2700/mm(3) in the afternoon). Due to these circadian changes, we decided to continue clozapine treatment.
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