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  • Title: Anti-inflammatory action of sulfoaryl 3,3-disubstituted triazenes in rat experimental edema models.
    Author: Kazemekaite M, Talaikyte Z, Udrenaite E, Labanauskas L, Staniulyte Z, Palaima A.
    Journal: Pharmazie; 2003 Oct; 58(10):730-2. PubMed ID: 14609286.
    Abstract:
    The acute toxicity and anti-inflammatory activity of eleven potassium salts of sulfobenzene and sulfonaphthalene 3,3-disubstituted triazenes have been examined in rats with carrageenin- and bentonite-induced edema using a 50 mg/kg p.o. dose. All compounds were found to exhibit anti-inflammatory activity significantly exceeding that of acetylsalicylic acid and ibuprofen, and were less toxic than these reference drugs. The most pronounced anti-inflammatory activity was shown by the potassium salt of 4-(piperazin-1-ylazo)benzenesulfonic acid.
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