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  • Title: [NK cell-based immunotherapy: new prospects and involvement of dendritic cells].
    Author: Borg C, Taieb J, Terme M, Maruyama K, Flament C, Angevin E, Zitvogel L.
    Journal: Bull Cancer; 2003; 90(8-9):699-705. PubMed ID: 14609759.
    Abstract:
    Dendritic cells (DC) were initially described as antigen presenting cells able to prime naive T cells. In fact, dendritic cells are also able to activate natural killer (NK) cells. The crosstalk between DC and NK is now regarded as a main stage in the initiation of innate and adaptative immune responses. Moreover, DC mediated-NK cell activation is particularly efficient since DC promote both effector functions and survival or proliferation of NK cells. Furthermore, recent publications in the field of NK cell biology underscore a role for NK cells in anti-tumor effects. NK cell-based immunotherapy should be reconsidered Here, we will report how pioneering immunotherapy trials based on natural cytotoxicity and progress in NK cell biology can promote NK cells in anti-tumor immune responses. Then, we will discuss the biological features of the DC/NK crosstalk and its implementations in immunotherapy protocols.
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