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  • Title: [G894T mutation of the endothelial nitric oxide synthase gene in Chinese Han nationality].
    Author: Wei DH, Li W, Hu YH, Chen ZM, Shan J.
    Journal: Zhejiang Da Xue Xue Bao Yi Xue Ban; 2003 Oct; 32(5):415-7, 426. PubMed ID: 14610742.
    Abstract:
    OBJECTIVE: To investigate the distribution of G894T mutation of the endothelial nitric oxide synthase (eNOS) gene in Chinese Han nationality. METHODS: G894T mutation of the eNOS gene of 108 unrelated healthy individuals was studied by means of polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) analysis. RESULT: All subjects were genotyped for eNOS gene; the frequencies of the GG, GT and TT genotypes were 0.9095, 0.0883 and 0.0021, respectively. In the Han nationality, the frequency of the GT, TT genotypes was lower than that in Japanese and Caucasian of UK (P< 0.05). CONCLUSION: These results suggest that there are significant differences in G894T mutation of eNOS gene between the Chinese Han nationality and other ethnic populations.
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