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  • Title: Naturally occurring SLE anti-DNA antibodies recognize unique conformation on DNA-lysine photoadduct.
    Author: Alam K, Islam N, Hasan R, Ali A, Ali R.
    Journal: Microbiol Immunol; 1992; 36(9):1003-7. PubMed ID: 1461148.
    Abstract:
    Native calf thymus DNA has been covalently modified with lysine under UV-A light. Human autoantibodies on purification through affinity column of native DNA linked to polylysyl-Sepharose 4B showed almost equal recognition of DNA and photoadduct. The recognition of DNA-lysine photoadduct by the affinity-purified autoantibodies might be helpful in understanding their origin in SLE vis-à-vis the role of positively charged amino acids in the pathogenesis of autoimmune diseases.
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