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  • Title: Human sperm associated antigen 4 (SPAG4) is a potential cancer marker.
    Author: Kennedy C, Sebire K, de Kretser DM, O'Bryan MK.
    Journal: Cell Tissue Res; 2004 Feb; 315(2):279-83. PubMed ID: 14614621.
    Abstract:
    Using a combination of database screening and polymerase chain reaction analyses we have determined the sequence and structure of the human sperm tail associated gene SPAG4. SPAG4 is a 12-exon gene spanning approximately 5.2 kb on chromosome 20q11.23. It is expressed in a limited number of normal tissues, notably the pancreas and testis, but is switched on and greatly upregulated in a wide range of neoplastic tissues. The data therefore strongly suggests that SPAG4 expression is a potential clinically relevant cancer marker.
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