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  • Title: Toxin-gene profile heterogeneity among endemic invasive European group A streptococcal isolates.
    Author: Schmitz FJ, Beyer A, Charpentier E, Normark BH, Schade M, Fluit AC, Hafner D, Novak R.
    Journal: J Infect Dis; 2003 Nov 15; 188(10):1578-86. PubMed ID: 14624385.
    Abstract:
    We determined the toxin-gene profiles of 239 endemic, invasive group A streptococcal (GAS) isolates that circulated, within a 5-year period, in European university hospitals. Profiling was performed by use of multiplex polymerase chain reaction that screened for 9 streptococcal pyrogenic exotoxins (speA, speB, speC, speF, speG, speH, speJ, ssa, and smeZ). Analysis revealed that invasive GAS isolates do not share a common toxin-gene profile. Although all emm types were characterized by several different toxin-gene profiles, a predominance of 1 or 2 toxin-gene profiles could be observed, reflecting that a few invasive clones have spread successfully throughout the world. Remarkably, statistical pair-wise analysis of individual toxin genes revealed that strains that did not share the predominant profile still showed a nonrandom distribution of key toxin genes characteristic of the specific emm type. This could indicate that M proteins function, directly or indirectly, as barriers for horizontal gene exchange.
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