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  • Title: Effect of hydrophilicity and agmatine modification on degradation of poly(propylene fumarate-co-ethylene glycol) hydrogels.
    Author: Tanahashi K, Mikos AG.
    Journal: J Biomed Mater Res A; 2003 Dec 15; 67(4):1148-54. PubMed ID: 14624500.
    Abstract:
    We synthesized positively charged biodegradable hydrogels with different poly(propylene fumarate-co-ethylene glycol) [P(PF-co-EG)] block copolymers and agmatine-modified poly(ethylene glycol)-tethered fumarate [Agm-PEGF] by radical crosslinking and investigated the effect of copolymer composition and agmatine modification on their degradation. Hydrogels were incubated in phosphate-buffered saline (PBS) at 37 degrees C with periodic PBS changes. All hydrogels experienced a slight mass loss over 4 weeks, ranging from 10-20%. Hydrogels with a molar ratio of ethylene glycol repeating units to propylene fumarate repeating units (EG/PF) of 9.3 degraded faster than hydrogels with an EG/PF ratio of 0.6. Agmatine-modified hydrogels degraded faster than unmodified hydrogels. The weight swelling ratio of the hydrogels at pH 7 increased over 4 weeks while increases in the EG/PF ratio and agmatine modification showed greater swelling. After 2 weeks, degraded hydrogels swollen at pH 3 demonstrated significantly lower weight swelling ratios than at pH 5, 7, and 9. Our results suggest that the hydrophilicity of the P(PF-co-EG) copolymer and agmatine modification have a small effect on the degradation of P(PF-co-EG) hydrogels.
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