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  • Title: [Association of angiotensinogen gene polymorphism with hypertension in type 2 diabetic patients].
    Author: Xue YM, Guan MP, Liu SQ, Zhang Q, Zhou L.
    Journal: Di Yi Jun Yi Da Xue Xue Bao; 2003 Nov; 23(11):1191-3. PubMed ID: 14625185.
    Abstract:
    OBJECTIVE: To investigate the relationship between angiotensinogen (AGT) gene polymorphism and hypertension in type 2 diabetic patients. METHODS: A total of 240 patients with type 2 diabetes mellitus were divided into normotensive and hypertensive groups according to their blood pressure measurement, and their fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein and very-low-density lipoprotein were measured. The AGT genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: The distributions of AGT genotypes in normotensive and hypertensive groups were similar, and the frequency of M allele in female hypertensive patients was significantly higher than that in female normotensive patients. CONCLUSION: The M allele of AGT gene is probably related to hypertension in female type 2 diabetic patients.
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