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  • Title: [Evaluation of N-acetyl-beta-D-glucosaminidase (NAG) and its isoenzyme activities in the urine of children with primary and secondary hypertension].
    Author: Zoch-Zwierz W, Winiecka W, Tomaszewska B, Wierciński R.
    Journal: Wiad Lek; 1992 Jul; 45(13-14):498-502. PubMed ID: 1462566.
    Abstract:
    The total activity of N-acetyl-beta-D-glucosaminidase (NAG) and its isoenzymes A and B was determined in the urine of 18 children aged 9-18 years with essential hypertension and 21 with nephrogenic hypertension. The results were compared with those in a control group of 30 healthy children. The obtained results show that in children with stabilized hypertension (above the 95 centile) of essential type the proportion (above the 95 centile) of essential type the proportion of urinary isoenzymes are changes, with higher activity of the B isoenzyme. On the other hand, in children with nephrogenic hypertension the total activity and the activity of the B isoenzyme are increased. After reduction of blood pressure following hypotensive treatment (below the 90th centile) the activity of NAG and its isoenzymes was again normal in essential hypertension and was much reduced in nephrogenic hypertension. The study demonstrated that hypertension leads to transient damage to the proximal tubules which is reversed by effective hypotensive treatment.
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