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  • Title: [Clinical observation on treatment of aplastic anemia patients by zaizhang decoction combined with Western medicine].
    Author: Guo X, Zhang M, Zhang YX.
    Journal: Zhongguo Zhong Xi Yi Jie He Za Zhi; 2003 Oct; 23(10):730-2. PubMed ID: 14626182.
    Abstract:
    OBJECTIVE: To study the effect of Composite Zaizhang decoction (ZZD) on immune function of chronic aplastic anemia (CAA) patients. METHODS: To determine the levels of T-lymphocyte subset, serum tumor necrosis factor (TNF-alpha) and interleukin-2 (IL-2) in CAA patients before and after treatment, and to analyse the regulation of their changes comparatively with the group treated with conventional treatment and a normal control group. RESULTS: Before treatment, CD4 was lower, CD8 higher, CD4/CD8 ratio also lower, TNF-alpha and IL-2 were higher in the ZZD treated group than those in the normal control group, with significant difference (P < 0.05), but after ZZD treatment, these indexes were all inversely changed, as compared with those before treatment and with those in the control group, the difference was significant (P < 0.05). CONCLUSION: ZZD might relieve the hemopoietic inhibition so as to promote the recovery of hemopoietic function through improving the T-lymphocyte subset and reducing the release of hemopoietic negative ragulatory factors such as TNF-alpha and IL-2 etc.
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