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  • Title: Differences in regulatory properties between human and rat glucokinase regulatory protein.
    Author: Brocklehurst KJ, Davies RA, Agius L.
    Journal: Biochem J; 2004 Mar 01; 378(Pt 2):693-7. PubMed ID: 14627435.
    Abstract:
    The inhibition of glucokinase by rat and Xenopus GKRPs (glucokinase regulatory protein) is well documented. We report a comparison of the effects of human and rat GKRPs on glucokinase activity. Human GKRP is a more potent inhibitor of glucokinase than rat GKRP in the absence of fructose 6-phosphate or sorbitol 6-phosphate, and has a higher affinity for these ligands. However, human and rat GKRPs have similar affinities for fructose 1-phosphate and chloride. Residues that are not conserved between the rodent and human proteins affect both the affinity for fructose 6-phosphate and sorbitol 6-phosphate and the inhibitory potency of GKRP on glucokinase in the absence of these ligands.
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