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  • Title: On the mechanism of rat uterus desensitization to kallikrein.
    Author: Heneine IF, Feitosa MH, Beraldo WT, Oliveira GM, Pesquero JL.
    Journal: Agents Actions Suppl; 1992; 38 ( Pt 2)():115-9. PubMed ID: 1462820.
    Abstract:
    An inactive form of kallikrein prepared by iodination with cold iodine, did not show any enzymatic or oxytocic action. However, a competitive pattern between this inactive and active kallikrein was observed in rat uterus preparation: When the inactive form was applied several times in the muscle, a single dose of active kallikrein was unable to cause contraction, but a double dose elicited a response. The rhythmic movement caused by a singular dose of active kallikrein, had its time curtailed by adding the inactive kallikrein to the bath. The inactive kallikrein did not interfere with bradykinin activity.
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